Lipid Membrane-Binding Properties of Amphotericin B Deoxycholate (Fungizone) Using Surface Plasmon Resonance
نویسندگان
چکیده
منابع مشابه
Lipid membrane-binding properties of amphotericin B deoxycholate (Fungizone) using surface plasmon resonance.
In the present study, we developed an assay of interactions of amphotericin B (AmB) deoxycholate, Fungizone, with two model lipid membranes that mimicked mammal cell membranes and fungal membranes. We also analyzed the binding kinetics of the mammal cell membranes and fungal membranes using surface plasmon resonance (SPR). Fungizone showed a higher affinity for the model fungal membrane than th...
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The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.
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Amphotericin B as a lipid complex and as a deoxycholate suspension (Fungizone) was tested against murine blastomycosis. All doses of each form prolonged survival (P less than 0.05 to 0.001). Fungizone was more effective than lipid complex at doses of 0.8 mg/kg of body weight. However, lipid complex at 12.8 mg/kg was not toxic and superior in efficacy (P less than 0.001) to 2.0 mg of Fungizone p...
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ژورنال
عنوان ژورنال: Analytical Sciences
سال: 2013
ISSN: 0910-6340,1348-2246
DOI: 10.2116/analsci.29.697